Recombinant Mycobacterium smegmatis Expressing an ESAT6-CFP10 Fusion Protein Induces Anti-Mycobacterial Immune Responses and Protects Against Mycobacterium tuberculosis Challenge in Mice
نویسندگان
چکیده
منابع مشابه
Immune responses against Mycobacterium tuberculosis-specific proteins PE35 and CFP10 in mice immunized with recombinant Mycobacterium vaccae.
OBJECTIVE To clone and express Mycobacterium tuberculosis (M. tuberculosis) proteins PE35 and culture filtrate protein (CFP)10 in Mycobacterium vaccae (M. vaccae), and subsequently, evaluate the humoral and cellular immunity responses against these recombinant constructs in mice. METHODS The DNA of PE35 and CFP 10 genes were cloned into the shuttle plasmid pDE22, and the recombinant plasmids ...
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ژورنال
عنوان ژورنال: Scandinavian Journal of Immunology
سال: 2010
ISSN: 0300-9475
DOI: 10.1111/j.1365-3083.2010.02448.x